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80030030: Third Annual Johns Hopkins Traumatic Brain Injury Conference: Biomarkers in Brain Trauma

May 11, 2013
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Online registration is no longer available for this activity. Please contact our CME office at (410) 502-9634 for registration information.



Third Annual Johns Hopkins Traumatic Brain Injury Conference: Biomarkers in Brain Trauma Brochure Cover Image


ACCREDITATION STATEMENT
The Johns Hopkins University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
CREDIT DESIGNATION STATEMENT
The Johns Hopkins University School of Medicine designates this live activity for a maximum of 7.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
OTHER CREDIT
American Academy of Nurse Practitioners
American Academy of Nurse Practitioners (AANP) accepts AMA PRA Category 1 Credit™ from organizations accredited by the ACCME.
American Academy of Physician Assistants
American Academy of Physician Assistants (AAPA) accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME. Physician assistants may receive a maximum of 7.75 hours of Category 1 credit for completing this program.

American Nurses Credentialing Center
American Nurses Credentialing Center (ANCC) accepts AMA PRA Category 1 Credit™ from organizations accredited by the ACCME.
American Occupational Therapy Association, Inc. (AOTA)
The Johns Hopkins University School of Medicine is an AOTA Approved Provider of continuing education. AOTA does not endorse specific course content, products, or clinical procedures. .775 AOTA CEUs will be provided.
Contact Hours for Non-Physicians
The Johns Hopkins University has approved this activity for 7.75 contact hours for non-physicians.
National Athletic Trainers Association
The Johns Hopkins University School of Medicine is recognized by the Board of Certification, Inc. to offer continuing education for Certified Athletic Trainers.
Professional Counselors and Therapists
This CE Program has been approved by the Maryland Board of Professional Counselors and Therapists for Category A CEUs.
Psychologists
The Johns Hopkins University School of Medicine is authorized by the Maryland State Board of Examiners of Psychologists as a provider of continuing education. The Johns Hopkins University School of Medicine maintains responsibility for this program. A certificate for 7.75 CEUs will be awarded upon completion of this activity.
Social Workers
The Maryland Board of Social Work Examiners certifies that this program meets the criteria for 7.75 credit hours of Category 1 or 7.75 CEUs of continuing education for social workers and associates licensed in Maryland. The Johns Hopkins University School of Medicine is an approved sponsor of the Maryland Board of Social Work Examiners for continuing education credits for licensed social workers in Maryland

Description

Traumatic brain injury (TBI) is the leading cause of death and disability in the first four decades of life. A central concern in TBI is how to identify tissue injury and remodeling, and how such information can inform clinical decision-making, treatment, and prognostication. Neurologic biomarkers, quantitative indicators of brain dysfunction or damage, may be obtained via sampling of behavioral phenotypes, biological tissues (blood, CSF, brain interstitial fluid), electrophysiological recordings, or neuroimaging. Biomarker research has concentrated on single marker assays, however an emerging body of work suggests that multi-marker panels may enhance sensitivity and specificity for acute neurologic injury; there is also considerable interest in genomic, proteomic and lipidomic profiles. At the Third Annual Johns Hopkins TBI Conference, seminal research into TBI biomarkers will be presented and discussed by an interdisciplinary panel of experts who are internationally recognized for their work in the field.

Objectives

After attending this activity, the participant will demonstrate the ability to:

  • Use MRI to define structural and functional changes in brain after a traumatic injury
  • Use PET to identify inflammatory and metabolic changes in brain after trauma
  • Recognize clinical markers such as sleep, eye movements and gait that have the potential to serve as diagnostic and prognostic markers of mild traumatic brain injury
  • Describe prognostic markers of moderate/severe TBI.

Talks

May 11, 2013  8:00 AM to 8:10 AM

Welcome and Conference Goals

Stevens, Robert
none
May 11, 2013  8:00 AM to 8:10 AM

Welcome and Conference Goals

Rao, Vani
NA NA NA
May 11, 2013  8:10 AM to 9:35 AM

Session 1: Insights from Magnetic Resonance Imaging - Chair

Van Zijl, Peter
N/A
May 11, 2013  8:10 AM to 9:35 AM

Session 1: Insights from Magnetic Resonance Imaging - Chair

Everett, Allen
N/A
May 11, 2013  8:10 AM to 8:35 AM

Traumatic Alterations in White Matter

Brody, David
Identify strengths and weaknesses of current methods to identify traumatic alterations in brain white matter Discuss the importance of white matter injury in traumatic brain injury Discuss why a negative CT or MRI scan does not rule out traumatic brain injury
May 11, 2013  8:35 AM to 9:00 AM

Significance of Cortical Volume Changes After Head Injury

Diaz-Arrastia, Ramon
Identify the value and limitations of quantitative semi-automated image parcellation methods. Describe the relationship between regional brain atrophy and functional outcome. Describe the relationship between white matter injury and regional brain atrophy.
May 11, 2013  9:00 AM to 9:25 AM

Functional Brain Activation After Head Injury

Mayer, Andrew
Define the key methodological issues that exist in mild traumatic brain injury research when using functional imaging techniques. Compare and contrast functional connectivity and more traditional functional magnetic resonance imaging techniques. Critically evaluate current findings in fMRI research following brain injury.
May 11, 2013  9:25 AM to 9:35 AM

Session 1: Insights from Magnetic Resonance Imaging - Discussion and Questions and Answers

Brody, David
N/a
May 11, 2013  9:25 AM to 9:35 AM

Session 1: Insights from Magnetic Resonance Imaging - Discussion and Questions and Answers

Diaz-Arrastia, Ramon
May 11, 2013  9:25 AM to 9:35 AM

Session 1: Insights from Magnetic Resonance Imaging - Discussion and Questions and Answers

Mayer, Andrew
N/A
May 11, 2013  9:25 AM to 9:35 AM

Session 1: Insights from Magnetic Resonance Imaging - Discussion and Questions and Answers - Chair

Van Zijl, Peter
N/A
May 11, 2013  9:25 AM to 9:35 AM

Session 1: Insights from Magnetic Resonance Imaging - Discussion and Questions and Answers - Chair

Everett, Allen
N/A
May 11, 2013  9:50 AM to 10:15 AM

Molecular Imaging of Neuroinflammation: A Window Into Traumatic Brain Injury

Pomper, Martin
Explain the connection between microglial activation and PET brain imaging Describe how PET might be used to image neuroinflammation in mild TBI
May 11, 2013  9:50 AM to 10:50 AM

Session 2: Insights from Positron Emission Tomography - Chair

Smith, Gwenn
n/a
May 11, 2013  9:50 AM to 10:50 AM

Session 2: Insights from Positron Emission Tomography - Chair

Maruta, Jun
N/A
May 11, 2013  10:15 AM to 10:40 AM

PET Ligands to Explore Post-Traumatic Neurodegeneration

Wong, Dean
Exposure to PET/SPECT radioligands potentially useful for TBI Introduction to molecular neuroimaging technology Potential imaging research for TBI and clinical implications
May 11, 2013  10:40 AM to 10:50 AM

Session 2: Insights from Positron Emission Tomography - Discussion and Questions and Answers

Pomper, Martin
N/A n/a n/a
May 11, 2013  10:40 AM to 10:50 AM

Session 2: Insights from Positron Emission Tomography - Discussion and Questions and Answers

Wong, Dean
Exposure to PET/SPECT radioligands potentially useful for TBI Introduction to molecular neuroimaging technology Potential imaging research for TBI and clinical implications
May 11, 2013  10:40 AM to 10:50 AM

Session 2: Insights from Positron Emission Tomography - Discussion and Questions and Answers - Chair

Smith, Gwenn
n/a
May 11, 2013  10:40 AM to 10:50 AM

Session 2: Insights from Positron Emission Tomography - Discussion and Questions and Answers - Chair

Maruta, Jun
N/A
May 11, 2013  10:50 AM to 11:15 AM

Markers of Cell Death Following Central Nervous System Trauma

Faden, Alan
Describe the different mechanisms of cell death after traumatic brain injury Recognize that inhibiting one mechanism of cell death may exacerbate others Discuss optimate therapy requires modulating multiple cell death mechanisms
May 11, 2013  10:50 AM to 12:15 PM

Session 3: Celluar Markers - Chair

Rothstein, Jeffrey
na na na
May 11, 2013  10:50 AM to 12:15 PM

Session 3: Celluar Markers - Chair

Claassen, Jan
Identify markers of brain injury
May 11, 2013  11:15 AM to 11:40 AM

Lipid Markers in Brain Injury

Haughey, Norman
Identify basic classes of lipids and roles in cellular signaling Provide examples of lipids that are dysregulated in neurodegenerative conditions Link specific patterns of dysregulation to temporal changes in cognitive status
May 11, 2013  11:40 AM to 12:05 PM

Markers of Plasticity and Regeneration After CNS Trauma

Pelled, Galit
Identify functional and anatomical changes associated with post-TBI plasticity in animal models using functional MRI, DTI, extracellular and intracellular electrophysiology recordings techniques.
May 11, 2013  12:05 PM to 12:15 PM

Session 3: Celluar Markers - Discussion and Questions and Answers

Faden, Alan
N/A
May 11, 2013  12:05 PM to 12:15 PM

Session 3: Celluar Markers - Discussion and Questions and Answers

Haughey, Norman
May 11, 2013  12:05 PM to 12:15 PM

Session 3: Celluar Markers - Discussion and Questions and Answers

Pelled, Galit
Identify functional and anatomical changes associated with post-TBI plasticity in animal models using functional MRI, DTI, extracellular and intracellular electrophysiology recordings techniques.
May 11, 2013  12:05 PM to 12:15 PM

Session 3: Celluar Markers - Discussion and Questions and Answers - Chair

Rothstein, Jeffrey
na na na
May 11, 2013  12:05 PM to 12:15 PM

Session 3: Celluar Markers - Discussion and Questions and Answers - Chair

Claassen, Jan
Identify markers of brain injury
May 11, 2013  1:00 PM to 1:25 PM

Quantitative Electroencephalography in Mild TBI

Slobounov, Semyon
Identify abnormal EEG and behavioral markers in concussed individuals with no obvious clinical symptoms Choose clinical return to play protocol directly examining restoration of pathophysiology after concussion Explain current controversies in clinical management of concussion
May 11, 2013  1:00 PM to 2:50 PM

Session 4: Biomarkers in Mild Traumatic Brain Injury - Chair

Lyketsos, Constantine
N/A
May 11, 2013  1:00 PM to 2:50 PM

Session 4: Biomarkers in Mild Traumatic Brain Injury - Chair

Celnik, Pablo
list potential TBI recovery biomarkers
May 11, 2013  1:25 PM to 1:50 PM

Postural Abnormalties in Mild TBI

Buckley, Thomas
recognize the role of postural control in concussion management distinguish between static and dynamic assessment of postural control in concussion management compare and contrast the traditional evaluation techniques to novel research approaches for postural control in concussion management
May 11, 2013  1:50 PM to 2:15 PM

Eye Movement Abnormalties in Mild TBI

Maruta, Jun
identify abnormal eye movement during visual tracking of a moving target
May 11, 2013  2:15 PM to 2:40 PM

Sleep Disturbances in Mild TBI

Rao, Vani
Describe normal sleep pattern Identify Sleep Disturbances associated with TBI Critically analyze if sleep disturbances can serve as markers of TBI
May 11, 2013  2:40 PM to 2:50 PM

Session 4: Biomarkers in Mild Traumatic Brain Injury - Discussion and Questions and Answers

Slobounov, Semyon
Identify abnormal EEG and behavioral markers in concussed individuals with no obvious clinical symptoms Choose clinical return to play protocol directly examining restoration of pathophysiology after concussion Explain current controversies in clinical management of concussion
May 11, 2013  2:40 PM to 2:50 PM

Session 4: Biomarkers in Mild Traumatic Brain Injury - Discussion and Questions and Answers

Buckley, Thomas
recognize the role of postural control in concussion management distinguish between static and dynamic assessment of postural control in concussion management compare and contrast the traditional evaluation techniques to novel research approaches for postural control in concussion management
May 11, 2013  2:40 PM to 2:50 PM

Session 4: Biomarkers in Mild Traumatic Brain Injury - Discussion and Questions and Answers

Rao, Vani
Explain definition and controversies associated with mild TBI Explain diagnostic and prognostic markers of mild TBI Critically decide the best validated markers
May 11, 2013  2:40 PM to 2:50 PM

Session 4: Biomarkers in Mild Traumatic Brain Injury - Discussion and Questions and Answers - Chair

Lyketsos, Constantine
N/A
May 11, 2013  2:40 PM to 2:50 PM

Session 4: Biomarkers in Mild Traumatic Brain Injury - Discussion and Questions and Answers - Chair

Celnik, Pablo
Identify TBI recovery biomarkers
May 11, 2013  3:05 PM to 3:30 PM

MRI Prognosis in Moderate / Severe TBI

Stevens, Robert
Recognize anatomical predictors of recovery after moderate/severe TBI Identify the link between diffusion tensor imaging variables and traumatic white matter injury Define the significance of functional and effective connectivity changes following TBI
May 11, 2013  3:05 PM to 4:55 PM

Session 5: Biomarkers in Moderate and Severe TBI

Diaz-Arrastia, Ramon
Discuss the usefulness of circulating biochemical biomarkers for characterizing TBI Discuss modern approaches for multiplex biomarker assays Discuss the challenges facing the field in developing biomarkers for TBI.
May 11, 2013  3:05 PM to 4:55 PM

Session 5: Biomarkers in Moderate and Severe TBI - Chair

Ulatowski, John
Describe the currently studied biomarkers for traumatic brain injury Discuss if any of these markers are predictive of outcome after mild to moderate injury Discuss how the field of biomakers may translate to unique therapies
May 11, 2013  3:30 PM to 3:55 PM

Serum Biomarkers in Severe Brain Injury

Everett, Allen
Describe the role and limitations of circulating biomarkers in brain injury
May 11, 2013  3:55 PM to 4:20 PM

Alterations in Cerebral Autoregulation Following Severe TBI

Lee-Summers, Jennifer
Review disturbances in autoregulation that may occur after traumatic brain injury (TBI). Discuss methods of autoregulation monitoring. Introduce CPP-targeted therapies that optimize autoregulation for individual patients.
May 11, 2013  4:20 PM to 4:45 PM

Quantitative EEG Approaches to Severe Brain Injury

Claassen, Jan
Describe applications of advanced EEG processing to recognize acute brain injury
May 11, 2013  4:45 PM to 4:55 PM

Session 5: Biomarkers in Moderate and Severe TBI - Discussion and Questions and Answers

Stevens, Robert
none
May 11, 2013  4:45 PM to 4:55 PM

Session 5: Biomarkers in Moderate and Severe TBI - Discussion and Questions and Answers

Everett, Allen
N/A
May 11, 2013  4:45 PM to 4:55 PM

Session 5: Biomarkers in Moderate and Severe TBI - Discussion and Questions and Answers

Lee-Summers, Jennifer
N/A
May 11, 2013  4:45 PM to 4:55 PM

Session 5: Biomarkers in Moderate and Severe TBI - Discussion and Questions and Answers

Claassen, Jan
Understand applications of advanced EEG processing to understnad acute brain injury
May 11, 2013  4:45 PM to 4:55 PM

Session 5: Biomarkers in Moderate and Severe TBI - Discussion and Questions and Answers - Chair

Ulatowski, John
N/A
May 11, 2013  4:45 PM to 4:55 PM

Session 5: Biomarkers in Moderate and Severe TBI - Discussion and Questions and Answers - Chair

Diaz-Arrastia, Ramon
May 11, 2013  4:55 PM to 5:00 PM

Summary

Stevens, Robert
none
May 11, 2013  4:55 PM to 5:00 PM

Summary

Rao, Vani
Describe markers of mild TBI Critically analyze the best markers for diagnosis and prognosis Recognize available markers for clinical practice

Policy On Speaker And Provider Disclosure

It is the policy of the Johns Hopkins University School of Medicine that the speaker and provider disclose real or apparent conflicts of interest relating to the topics of this educational activity, and also disclose discussions of unlabeled/unapproved uses of drugs or devices during their presentation(s). Johns Hopkins University School of Medicine OCME has established policies in place that will identify and resolve all conflicts of interest prior to this educational activity. Detailed disclosure will be made in the activity handout materials.

Event Information
Johns Hopkins University School of Medicine, Turner Bldg.
720 Rutland Ave.
Baltimore, MD
Directions

Registration Fee(s)

Physicians – $ 275.00
Research Faculty, AHP – $ 150.00
Active Duty – $ 100.00
Employees of DoD, VA – $ 100.00
House Staff – $ 100.00
Nurse Practitioners – $ 150.00
Medical Students – $ 25.00
Residents, Post Doc Fellows – $ 25.00
Nurses – $ 25.00
Therapists – $ 25.00

Target Audience(s)

This activity is intended for health care professionals and researchers working in emergency medicine, trauma surgery, neurology, neurosurgery, psychiatry, physical medicine and rehabilitation, critical care medicine, sports medicine, and the military

Course Director

Robert Stevens

Course Co-Director

Vani Rao

Lodging

Baltimore Marriott Inner Harbor at Camden Yards
110 South Eutaw Street
Baltimore, MD 21201
Phone: (800) 468-3571 or
(410) 962-0202
Fax: (410) 625-7892

Hotel Website

www.baltimoremarriottinnerharbor.com

Contact Info

General Info: 410.502.9634

Mailing Address:
Johns Hopkins University School
of Medicine
Thomas B. Turner Building
720 Rutland Avenue, Room 20
Baltimore, Maryland 21205-2195

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