80025586: The 9th International Symposium on Functional Neuroreceptor Mapping of the Living Brain (NRM12)

Download Flier Here

ANNOUNCEMENTS
Oral Abstracts Presentation and Poster Guidelines Announcement

• Each oral abstract presentation speaker has approximately 17 minutes allotted including questions. Within that 17 minutes, ideally the speaker should allow 5 minutes for questions. Please see the Scientific Program on this Website for your assigned day and time of presentation.
• The poster size information was provided in the original notification acceptance letters to the authors. The dimensions are: No more than A0 in size (841mm x 1189mm) and portrait in format. At the meeting, presenting authors and their posters are assigned a specific date/time (see this Website for the Poster Session Listing). Thus, posters will be set up and taken down each day. We ask that posters be set up for display prior to the first session of each day and removed at the end of the daily poster session, which is the last session of the day.

SPM8 Announcement
SPM8 for PET and SPECT is an intermediate-level, 4-day data analysis workshop designed for investigators having familiarity with the fundamental principles of PET and SPECT data acquisition, and at least six months experience in analysis. A satellite meeting of The 9th International Symposium on Functional Neuroreceptor Mapping of the Living Brain (NRM12), it will be held at Johns Hopkins University in Baltimore, MD the week after NRM12 from AUG 14-17, 2012. Please follow this link to learn more about this workshop;
http://www.neurometrika.org/SPM_PET_Baltimore

Please click here for information on the Pharmacokinetic Modeling for Positron Emission Tomography Meeting.

ONLINE REGISTRATION IS NOW OPEN by credit card and eCheck only.

Please Download Registration Form Here

Please see NRM12 Full Scientific Programme.

Please see NRM12 Poster Sessions.

FEES

Early Bird Registration $700 until 5:00 p.m. EST on May 9, 2012.

Regular Registration $850 for registrations received after 5:00 p.m. on May 9, 2012 until 5:00 p.m. August 3, 2012 EST.

METHODS OF PAYMENT Payment by check or credit card must accompany the registration form prior to the activity. On-site payments by credit card only. Foreign payments must be by credit card or with a U.S. Dollar World Money Order. The registration fee includes instructional materials, continential breakfasts (2) days, refreshment breaks during the day and during poster sessions, lunches (2) days, opening reception and closing banquet.

You will receive a confirmation by e-mail if you have provided your e-mail address. Otherwise confirmation will be sent by mail. If you have not received it by August 3, 2012, call (410) 502-9634 to confirm that you are registered. A certificate of attendance will be sent by September 25, 2012 to the e-mail address you provide on your registration form.

The Johns Hopkins University reserves the right to cancel or postpone any activity due to unforeseen circumstances. In this event, the University will refund the registration fee but is not responsible for travel expenses. Additionally, we reserve the right to change the venue to a comparable venue. Under such circumstances registrants will be notified as soon as possible.

LATE FEE AND REFUND POLICY A $50 late fee applies to registrations received after 5:00 p.m. EST on August 3, 2012. A handling fee of $50 will be deducted for cancellation. Refund requests must be received by fax or mail by August 3, 2012. No refunds will be made thereafter. Transfer of registration to another Johns Hopkins conference in lieu of cancellation is not possible.

HOTEL AND TRAVEL INFORMATION
We strongly encourage you to book your accommodations at the Hyatt Regency Baltimore Hotel, which is the confernce headquarters. The Johns Hopkins Office of CME makes every effort to secure the best rate for overnight accommodations. The rate is part of a negotiated conference package that incorporates many services. By staying at the host hotel and booking within the room block, you help us maintain current conference benefits and keep future registration fees reasonable. Please consider this when making your overnight accommodations decision.

Hyatt Regency Baltimore Hotel
300 Light Street
Baltimore, Maryland 21202
(410) 528-1234

HOTEL RESERVATION CUT-OFF DATE: JULY 20, 2012

A limted block of sleeping rooms has been reserved for your convenience and will be available on a first come, first served basis.

The Hyatt Regency Baltimore, centrally located on the Inner Harbor and an industry leader since its opening, holds the longest four-diamond award status in the state with beautiful guestrooms, Bistro 300 and a commitment to excellent service. Click Here to make your reservation online at or call the hotel directly and specify that you are attending the Johns Hopkins International Symposium on Functional Neuroreceptor Mapping of the Living Brain to receive the special group rate of $169, single or double, plus 15.5% taxes. On-site parking is available at an additional charge. Check-in time is 4:00 p.m. Check out time is 12:00 noon.

Daily complimentary roundtrip transportation (3 miles one way) will be provided between the Hyatt Regency Baltimore and the Johns Hopkins University School of Medicine for the symposium.

FLIGHTS FROM EUROPE TO BALTIMORE/WASHINGTON INTERNATIONAL AIRPORT

Condor Air has seasonal direct flights from Germany to BWI and back during our meeting.

For questions or concerns related to hotel and meeting registration, please email cmenet@jhmi.edu.

For questions related to abstract submission, please email abstracts@nrm12.org.

For preliminary scientific/logistical information and other questions, please email nrm12@jhmi.edu.

Talks

August 9, 2012  1:00 PM to 1:15 PM

Introduction and Welcome Address

Wong, Dean

August 9, 2012  1:15 PM to 1:20 PM

Young Scientist Awards Announcement

Smith, Gwenn

August 9, 2012  1:20 PM to 2:00 PM

Opening Remarks - Brain in the Dome: Back to the Future of Mapping Neuroreceptors at Work

Gjedde, Albert

August 9, 2012  2:00 PM to 2:18 PM

O1: Changes in Striatal Dopamine in Response to IV Alcohol in Nontreatment-Seeking Alcohol but not Social Drinkers

Yoder, Karmen

Discuss how the brain dopamine response to an alcohol stimulus may be different in alcoholics and social drinkers.

August 9, 2012  2:00 PM to 3:10 PM

Session 1 - Mapping Dopamine Receptors at Work - Moderator

Grunder, Gerhard

I will only act as a moderator.

August 9, 2012  2:18 PM to 2:35 PM

O2: Relationships of D1- and D2-like Receptor Availability and Response Inhibition in the Stop-Signal Task: A Preliminary PET Study

Robertson, Chelsea

N/A

August 9, 2012  2:35 PM to 2:53 PM

O3: Diurnal Changes in the Available Dopamine D2/D3 Receptor Density Suggests Decreased Intrasynaptic Dopamine at Night

Kuwabara, Hiroto

understand better about diurnal changes in endogenous dopamines that occupy dopamine recptors.

August 9, 2012  2:53 PM to 3:10 PM

O4: The Relation between Body Mass Index and Dopamine D2 Receptor Availability in the Caudate: A PET Study in Humans

Bolling, Danielle

Understand the relation between dopamine receptor availability in the striatum, and body mass index, and the implications of this relationship in obesity.

August 10, 2012  8:00 AM to 9:10 AM

Session 2 - Novel Radiotracers for Brain Mapping - Moderator

Ding, Yu-Shin

N/A

August 10, 2012  8:00 AM to 8:18 AM

O5: Evaluation of a Small Library of Carbamates and Ureas, including PF-04457845, as Potential Imaging Agents for Fatty Acid Amide Hydrolase (FAAH)

Wilson, Alan

August 10, 2012  8:18 AM to 8:35 AM

O6: Human PET Imaging with [11C]JNJ=42491293, a Tracer for the mGIuR2 Positive Allosteric Site

Schmidt, Mark

August 10, 2012  8:35 AM to 8:53 AM

O7: A Novel PET Radiotracer for Imaging the Kappa Opioid Receptor

Zheng, Mingqiang

1.Describe the current pre-clinical and clinical PET studies for kappa opioid receptor; 2.Evaluate the candidate radioligands as a potential PET tracers for human use.

August 10, 2012  8:53 AM to 9:10 AM

O8: [11C]Elacridar, a PET Radiotracer to Measure the Function of P-glycoprotein and Breast Cancer Resistance Protein at the Blood-Brain Barrier: First Assessment in Healthy Human Subjects

Bauer, Martin

August 10, 2012  9:30 AM to 11:40 AM

Session 3 - Pathophysiology of Inflammation - Moderator

Pomper, Martin

n/a

August 10, 2012  9:30 AM to 10:40 AM

Session 3 - Pathophysiology of Inflammation - Moderator

Innis, Robert

I am only the moderator and not the lecturer. Thus, I have no specific learning objectives.

August 10, 2012  9:30 AM to 9:48 AM

O9: Validation of SUV as an Outcome Measure of [11C]PBR28 in Rat Using PET/MRI

Doorduin, Janine

recognize that the SUV can be used to describe [11C]PBR28 uptake in the healthy rat brain.

August 10, 2012  9:48 AM to 10:05 AM

O10: Correcting for the Ala 147Thr Polymorphism in the Gene for 18 kDa Translocator Protein Improves Quantification of This Inflammatory Biomarker with [11C]PBR28

Kreisl, William

Understand the influence of genotype on PET imaging with [11C]PBR28 and how to overcome this potential confound in clinical PET studies.

August 10, 2012  10:05 AM to 10:23 AM

O11: [18F]PBR111 Binding in Multiple Sclerosis: Relationship to Age and Clinical Variables

Colasanti, Alessandro

discuss the use of TSPO PET ligand to monitor neuroinflammation in Multiple Sclerosis

August 10, 2012  10:23 AM to 10:40 AM

O12: Imaging Activated Microglia in Parkinson's Disease: A PET Study with Novel Radiotracer, [18F]FEPPA

Ko, Ji Hyun

August 10, 2012  10:40 AM to 11:40 AM

Plenary Lecture II - Molecular Imaging in Drug Addiction

Volkow, Nora

August 10, 2012  12:40 PM to 1:40 PM

Workshop I - Cognitive Effects on Neurotransmission: How Strong is the Evidence? - Convener

London, Edythe

August 10, 2012  12:40 PM to 1:40 PM

Workshop I - Cognitive Effects on Neurotransmissions: How Strong is the Evidence? - Convener

Berman, Karen

August 10, 2012  1:40 PM to 2:50 PM

Session 4 - Cannabinoid Mechanisms in Addiction and Neuropsychiatric Disorders - Moderator

Van Laere , Koen

August 10, 2012  1:40 PM to 2:50 PM

Session 4 - Cannabinoid Mechanisms in Addiction and Neuropsychiatric Disorders - Moderator

Horti, Andrew

August 10, 2012  1:40 PM to 1:58 PM

O13: Low Brain CB1 Receptor Occupancy by a Second Generation CB1 Antagonist TM38837 in Comparison with Rimonabant in Nonhuman Primates

Takano, Akihiro

understand how low the CB1 receptor occupany by a second generation CB1 antagonist TM38837 is in comparison with a first generation CB1 antagonist rimonabant.

August 10, 2012  1:58 PM to 2:15 PM

O14: The Use of [11C]OMAR and Positron Emission Tomography to Investigate the Pathophysiology of Posttraumatic Stress Disorder

Bailey, Christopher

After attending this lecture, the participant will demonstrate the ability to... (1) Understand the hypothesized role of the cannabinoid system in stress disorders such as posttraumatic stress disorder (PTSD) (2) Understand our application of [11C]OMAR to investigate the pathophysiology of PTSD (3) Describe our findings of altered CB1 receptor density in patients with PTSD

August 10, 2012  2:15 PM to 2:33 PM

O15: Mapping CB1 Cannabinoid Receptors with [3H]OMAR in the Flinders Rodent Model of Depression

Nahimi, Adjmal

This talk addresses the cannabinoid system in a rodent model of depression and anxiety.

August 10, 2012  2:33 PM to 2:50 PM

O16: Reduced Cannabinoid CB1 Receptor Binding in Alcohol Dependence Measures with Positron Emission Tomography

Hirvonen, Jussi

Understand the use of positron emission tomography to image cannabinoid CB1 receptors in human brain, and explain findings in CB1 receptors in patients with alcohol dependence.

August 10, 2012  3:10 PM to 4:20 PM

Session 5 - Advances in Imaging the Glutamate System - Moderator

Rothstein, Jeffrey

August 10, 2012  3:10 PM to 4:20 PM

Session 5 - Advances in Imaging the Glutamate System - Moderator

Borroni, Edilio

August 10, 2012  3:10 PM to 3:28 PM

O17: PET Imaging of the Excitatory Amino Acid Transporter 2 in an Amyotrophic Lateral Sclerosis Rat Model

Gerdes, John

The objective of this lecture is to convey state-of-the-art scientific information regarding positron emission tomography (PET) imaging of a rodent model of the neurodegenerative disorder amyotrophic lateral sclerosis (ALS). At the end of this lecture the participant will have the ability to perform specific PET imaging studies that detect changes to the excitatory amino acid transporter 2 (EAAT2) target protein in the central nervous system of rats.

August 10, 2012  3:28 PM to 3:45 PM

O18: Metabotropic Glutamate Receptor 5 Radioligand [11C]ABP688 and N-Acetylcysteine Challenges in Rhesus Monkeys

Sandiego, Christine

The objective of this presentation is to discuss the potential for detecting changes in glutamate release after administration of the glutamate releasing agent, N-Acetylcysteine, at the metabotropic glutamate receptor 5 with radioligand, [11C]ABP688, in rhesus monkeys. Particular relevance for this study is aimed towards learning about dysfunction in glutamate neurotransmission associated with neuropsychiatric illnesses in humans.

August 10, 2012  3:45 PM to 4:03 PM

O19: Tracer Kinetic Modeling of [11C]JNJ42491293, a PET Ligand for the mGluR2 Receptor in the Human Brain

Koole, Michel

August 10, 2012  4:03 PM to 4:20 PM

O20: PET Imaging of the Metabotropic Glutamate Receptor Type 5 in Cocaine Abuse

Martinez, Diana

August 10, 2012  4:20 PM to 5:20 PM

Workshop II - Outcome Measures: How Many and How Different?

Gjedde, Albert

August 10, 2012  4:20 PM to 5:20 PM

Workshop II - Outcome Measures: How Many and How Different?

Kuwabara, Hiroto

understand what receptor and transporter-related biological variables can be measured with positron emission tomography (PET)

August 11, 2012  8:00 AM to 9:10 AM

Session 6 - Novel Applications of Serotonin Imaging - Moderator

Doudet, Doris

August 11, 2012  8:00 AM to 9:10 AM

Session 6 - Novel Applications of Serotonin Imaging - Moderator

Smith, Gwenn

August 11, 2012  8:00 AM to 9:10 AM

Session 6 - Novel Applications of Serotonin Imaging - Moderator

Smith, Gwenn

August 11, 2012  8:00 AM to 8:18 AM

O21: Examination of Structural Connectivity in Depression: Anti-Depressant Remitters versus Non-Remitters

Delorenzo, Christine

understand DTI and PET derived measures that may be used to distinguish anti-depressant remitters from non-remitters.

August 11, 2012  8:18 AM to 8:35 AM

O22: Treatment Response in Major Depression Predicted by Serotonin Transporter Interplay

Lanzenberger, Rupert

August 11, 2012  8:35 AM to 8:53 AM

O23: PET Imaging of Serotonin Transporter in Monkeys: Effects of Maternal Separation, and Long-term Fluoxetine Treatment during Adolescence

Shrestha, Saurav

This lecture demonstrates serotoninergic alterations in maternal-separated monkeys, and chronic flouxetine treatment may reverse deficits in SERT density that is persistent more than one year after medication discontinuation.

August 11, 2012  8:53 AM to 9:10 AM

O24: Serotonin-1A Receptor-dependent Modulation of the Default Mode Network

Hahn, Andreas

August 11, 2012  9:30 AM to 10:40 AM

Session 7 - Reference Plots: Issues and Solutions - Moderator

Gunn, Roger

August 11, 2012  9:30 AM to 10:40 AM

Session 7 - Reference Plots: Issues and Solutions - Moderator

Zhou, Yun

N/A

August 11, 2012  9:30 AM to 9:48 AM

O25: Estimation of the Linearity Point in Graphical Analysis

Ogden, R. Todd

August 11, 2012  9:48 AM to 10:05 AM

O26: Limitations of SRTM, Logan Plot, and Equilibrium Analysis for Measuring Transient Dopamine Release in [11C]Raclopride PET Studies

Sullivan, Jenna

– Describe the limitations of SRTM, Logan Plot, and equilibrium analysis in measuring transient dopamine release with [11C]raclopride PET. – Decide if analysis methods should be applied to their imaging data.

August 11, 2012  10:05 AM to 10:23 AM

O27: Validation of the Partial Saturation Approach for In Vivo Qualification of Striatal Dopamine D2 Receptors with [11C]Raclopride

Wimberley, Catriona

Goal: - The aim of this study was to investigate whether the PSA produces stable and accurate parameter estimates of pharmacological or disease-induced changes in appBmax and appKd for [11C]Raclopride in the rodent. Objective: At the end of this activity, the participant will demonstrate the ability to: - Describe the partial saturation approach (PSA) - Identify the assumptions of the method and recognise why it is necessary adapt the method based on the validation of the assumption - Recognise the potential of the method described for use to study pharmacological or disease induced changes in appBmax and appKd for [11C]raclopride in the rodent

August 11, 2012  10:23 AM to 10:40 AM

O28: Update: Inhibition Plots of [11C]Yohimbine Binding Yield Consistent Estimates of Non-displaceable Volumes of Distribution in Multiple Tests

Gjedde, Albert

August 11, 2012  10:40 AM to 11:40 AM

Workshop III - Reward Deficiency Disorders: Do They Really Exist? - Convener

Kessler, Robert

1. To understand the relationship between DA neurotransmission, reward function, and body mass index

August 11, 2012  10:40 AM to 11:40 AM

Workshop III - Reward Deficiency Disorders: Do They Really Exist? - Convener

Hammers, Alexander

August 11, 2012  1:40 PM to 2:50 PM

Session 8 - Interpreting In Vivo Amyloid Imaging - Moderator

Forsberg, Anton

August 11, 2012  1:40 PM to 1:58 PM

O29: The Detectability of Aß Amyloid by Florbetapir F18 PET Imaging in Mouse Models of Alzheimer's Disease with Different Rates of Plaque Accumulation

Savonenko, Alena

understand utilization of PET tracers to detect brain Ab amyloid plaque load in vivo and possible limitations of Ab PET signal in diagnosis of Alzheimer's disease

August 11, 2012  1:58 PM to 2:15 PM

O30: [11C]PiB PET and Post-mortem Measures of Amyloid Load: Regional Correspondence

Price, Julie

August 11, 2012  2:15 PM to 2:33 AM

O31: Quantitative Assessment of Longitudinal Amyloid Imaging Using [11C]PiB: Impact of Flow Variation

Boellaard, Ronald

Understand pro's and con's for using SUVR and SRTM for measuring longitudinal changes in PIB binding.

August 11, 2012  2:33 PM to 2:50 PM

O32: Combined CBF and Binding Analyses with Single 11C-PIB PET Session in Alzheimer's Disease and Healthy Controls

Rodell, Anders

Pittsburg compound B binding is dependent on blood flow, When this is taken into account it provides better understanding of this tracer for use in Alzheimers disease

August 11, 2012  4:10 PM to 4:45 PM

NRM2014 Conference Presentations

Wong, Dean

Policy On Speaker And Provider Disclosure

It is the policy of the Johns Hopkins University School of Medicine that the speaker and provider disclose real or apparent conflicts of interest relating to the topics of this educational activity, and also disclose discussions of unlabeled/unapproved uses of drugs or devices during their presentation(s). Johns Hopkins University School of Medicine OCME has established policies in place that will identify and resolve all conflicts of interest prior to this educational activity. Detailed disclosure will be made in the activity handout materials.